The Nature Communications journal in 2019 published a group study in Denmark, when the dietary and other habits of 56,000 participants of 50-60-year old (on entry) were monitored for 23 years, and at the end of the study they summarized how the consumption of flavonoids may have contributed to their health. During the study, 14,000 people died, in which low daily flavonoid intake was a significant risk factor.
According to the conclusions, those who consumed food and drink containing at least 500mg flavonoids, were more likely to survive until the end of the study. When the death rate had been focused on cardiovascular diseases, the low-flavonoid intake was also a risk factor, so a greater chance for a fatal cardiovascular disease of the patient within the period of the experiment.
The study separately examined the mortality rate of those with harmful passions. The protective effect of flavonoids was more pronounced if someone smoked or regularly consumed alcohol, which may be because in addition to supporting the body, the harmful effects of tobacco smoke and alcohol on the body could be offset by a diet rich in flavonoids.
An Australian study published in early 2020, which monitored participants with an average age of 65 years for 14 years, confirmed the conclusions of the Danish study that a minimum of 500-700 mg of flavonoids per day should be administered to reduce the risk of death.
In a 2018 study, 20-month-old elderly mice (based on the physiological functions they can be considered as humans at the age of 75 years) were given feed rich in flavonoids called fisetin. The control group lived an average of 27 months, while the other group on the supplementation of fisetin lived 3 months longer compared to the control group, on average 30 months, which means more than 10% life growth.
- Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. Nat Commun. 2019; 10: 3651.
- Association of flavonoids and flavonoid-rich foods with all-cause mortality: The Blue Mountains Eye Study. Clin Nutr. 2020; 39(1):141-150.
- Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018; 36: 18–28.