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Herbal combination

Basemix

Dietary supplement containing sorghum seed and peel, asparagus sprouts and alfalfa sprouts with citrus bioflavonoid extract.

25.400Ft

(75 €)

Out of stock

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Gout, a modern folk disease

Gout is accompanied by recurrent acute arthritis. Patients suffer from sudden, even mid-night flare-up pain. Acute inflammation occurs primarily in the big toe, but can also develop in other joints of the foot (knee, ankle), and less commonly, the joints of the arm (wrist, elbow) and spine may also be affected.

The cause of the pain is the formation of needle-like uric acid crystals in the joints, which can also result in partial restriction of movement, making daily life more difficult. If gout is not treated, gout attacks can become more common and can lead to serious complications such as kidney failure because crystals can form within the kidney over time.

The appearance of gout can be caused by a disorder in the body's purine metabolism or by a malfunction of the renal excretion of uric acid.

In both cases, uric acid is produced in the body faster from the breakdown of purine than it could be excreted in the urine. Because uric acid is a end product in the human body, it can no longer transform (break down), its amount begins to rise in the blood. When uric acid levels reach a critical concentration, tiny uric acid crystals begin to deposit in the joints first, causing redness and swelling initially, followed by inflammation and burning pain.

The normal level of uric acid in the blood serum is in males 2.9-5.8 mg/dl, for women 2.4-4.3 mg/dl, but after menopause this value may be higher. As uric acid levels are considered acceptable below 6 mg/dl, even a small permanent increase can lead to a problem, especially for men.

What factors can influence the risk?

The development of gout can be greatly redounded by lifestyle habits. Eating large amounts of high purine foods (offal, meat, seafood) produces more uric acid, which takes more time to excrete. Consumption of sugary soft-drinks with a high fructose content can also lead to an increase in uric acid levels because purine synthesis is induced in parallel with the breakdown of fructose. In addition, regular alcohol consumption and obesity can greatly increase the risk of gout. For the above nutritional reasons, gout was previously considered a ‘disease of the rich’ because regular consumption of meat and alcohol could only be afforded by a close circle.

Genetic factors may cause the development of gout. One of the most important is a molecular pump called ABCG2, which is responsible for removing uric acid from the body. Some rarer variants of this protein are less effective in excreting uric acid in the urine. ABCG2 pump variants that pose a risk for gout development are found in all populations, but are more common in indigenous tribes in East Asia and the United States.

Science behind

Science against Gout

For the symptomatic treatment of gout, various steroid and non-steroidal anti-inflammatory drugs can be given today to relieve the pain associated with it. Reductions in uric acid levels are sought by switching to a purine-poor diet and various enzyme inhibitors.

Once a person has had a gout disease, lifelong medication is often recommended to prevent recurrence, which - in turn - can cause discomfort due to the side effects of the medication.

Science

Gout develops as a result of high uric acid levels. The flavonoid called hesperidin found in citrus fruits but slightly was able to reduce uric acid in the blood in rats, because it inhibited the production of a key enzyme, xanthine oxidase, of uric acid. A more absorbable, glycosylated version of hesperidin was also able to do so in mice fed a fructose-rich diet to induce high uric acid levels. In addition to hesperidin, the citrus flavonoids naringenin, nobiletin, and hesperetin are also potentials, because they inhibited a transporter that could return uric acid from the renal tubules to the bloodstream. Furthermore, in studies in mice, naringenin reduced the inflammation and pain associated with gout.

Sources:

  • Orange Juice and Hesperetin Supplementation to Hyperuricemic Rats Alter Oxidative Stress Markers and Xanthine Oxidoreductase Activity. J Clin Biochem Nutr. 2009; 45(3): 285–291.
  • Comprehensive Analysis of Mechanism Underlying Hypouricemic Effect of Glucosyl Hesperidin. Biochem B Res Comm. 2020; 521(4):861-867.
  • Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate. NPJ Sci Food. 2020; 4:3.
  • The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β. J Funct Foods. 2018; 48:106-116.

Many bioactive components can be found in plants that have an anti-inflammatory effect. Both sorghum seeds and alfalfa sprouts have such components, which has been confirmed by several experiments. In some plants, such as asparagus shoots, so-called galactolipids also occur, which may be a potential support for arthritis, among others.

Sources:

  • Grain and Sweet Sorghum (Sorghum Bicolor L. Moench) Serves as a Novel Source of Bioactive Compounds for Human Health. Crit Rev Food Sci Nutr. 2018; 58(17):2867-2881.
  • Ethyl Acetate Extracts of Alfalfa (Medicago Sativa L.) Sprouts Inhibit Lipopolysaccharide-Induced Inflammation in Vitro and in Vivo. J Biomed Sci. 2009; 16(1):64.
  • Galactolipids as Potential Health Promoting Compounds in Vegetable Foods. Recent Pat Food Nutr Agric. 2009; 1(1):50-8.

Gout develops as a result of high uric acid levels. The flavonoid called hesperidin found in citrus fruits but slightly was able to reduce uric acid in the blood in rats, because it inhibited the production of a key enzyme, xanthine oxidase, of uric acid. A more absorbable, glycosylated version of hesperidin was also able to do so in mice fed a fructose-rich diet to induce high uric acid levels. In addition to hesperidin, the citrus flavonoids naringenin, nobiletin, and hesperetin are also potentials, because they inhibited a transporter that could return uric acid from the renal tubules to the bloodstream. Furthermore, in studies in mice, naringenin reduced the inflammation and pain associated with gout.

Sources:

  • Orange Juice and Hesperetin Supplementation to Hyperuricemic Rats Alter Oxidative Stress Markers and Xanthine Oxidoreductase Activity. J Clin Biochem Nutr. 2009; 45(3): 285–291.
  • Comprehensive Analysis of Mechanism Underlying Hypouricemic Effect of Glucosyl Hesperidin. Biochem B Res Comm. 2020; 521(4):861-867.
  • Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate. NPJ Sci Food. 2020; 4:3.
  • The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β. J Funct Foods. 2018; 48:106-116.

Many bioactive components can be found in plants that have an anti-inflammatory effect. Both sorghum seeds and alfalfa sprouts have such components, which has been confirmed by several experiments. In some plants, such as asparagus shoots, so-called galactolipids also occur, which may be a potential support for arthritis, among others.

Sources:

  • Grain and Sweet Sorghum (Sorghum Bicolor L. Moench) Serves as a Novel Source of Bioactive Compounds for Human Health. Crit Rev Food Sci Nutr. 2018; 58(17):2867-2881.
  • Ethyl Acetate Extracts of Alfalfa (Medicago Sativa L.) Sprouts Inhibit Lipopolysaccharide-Induced Inflammation in Vitro and in Vivo. J Biomed Sci. 2009; 16(1):64.
  • Galactolipids as Potential Health Promoting Compounds in Vegetable Foods. Recent Pat Food Nutr Agric. 2009; 1(1):50-8.

Gout

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Ingredients
Active ingredients in a daily dose2 capsules4 capsules
Asparagus sprouts grit200 mg400 mg
Lucerne sprouts grit200 mg400 mg
Bioflavonoids114 mg228 mg

Sorghum seed-carapace, Asparagus sprouts, Aspartic acid, chlorophyll, Lucerne sprouts, L-succinic acid, Cobalamin, Menakinon, Citrus aurantium (Citrus bioflavonoid), Gelatin.

Dosage

Consumption of 4 boxes is recommended: Box 1: 3x2 capsules daily; Box 2: 2x2 capsules daily; Box: 3-4.: 2x1 capsule daily. After meals.

Packaging

100 capsules

Shelf life

For 3 years from production. The date of manufacture and expiry are indicated on the packaging.

Storage

Avoid direct sunlight; in a dry, cool place.

Notice

For long-term effect, the product is suggested to be combined with STEMAX or STEMAX SL and CorsyMAX 10x products that will help restore kidney and liver function.

Daily dose should not be exceeded!

- Drink fair amount of water!
- Dietary supplements are not substitutes for a balanced diet.
- Dietary supplements are not medicines, nor substitutes for medicines!
- Keep out of the reach of children.

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Bioflavonoid Complex

Flavita Family

Products of our FLAVITA product family contain concentrated flavonoids and other valuable plant antioxidants in the form of capsules or syrups.